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New York – Some researchers, whose study was published in the journal Science Avances, have created a nanoparticle platform to facilitate successful delivery of therapeutic agents to the brain. Although they have in the past decade identified biological pathways leading to neurodegenerative diseases and developed promising molecular agents to target them, delivering therapeutics across the blood-brain barrier (BBB) and into the brain has been a challenge. It could open possibilities for treatment of numerous neurological disorders.
This platform can facilitate therapeutically effective delivery of encapsulated agents in mice with a physically breached or intact blood-brain barrier. Corresponding author Nitin Joshi from Brigham and Women’s Hospital in the US, said: “It’s very difficult to get both small and large molecule therapeutic agents delivered across the BBB. Our solution was to encapsulate therapeutic agents into biocompatible nanoparticles with precisely engineered surface properties that would enable their therapeutically effective transport into the brain, independent of the state of the BBB.”
The technology could enable physicians to treat secondary injuries associated with traumatic brain injury that can lead to Alzheimer’s, Parkinson’s, and other neurodegenerative diseases, which can develop during ensuing months and years once the blood-brain barrier has healed.
